P-212 βhCG concentration in peripherical maternal blood after single embryo transfer, ongoing pregnancy rates and morphokinetics

Abstract Study question Is there a relationship between the concentration of βhCG hormone in maternal blood, embryo morphokinetics and clinical outcome? Summary answer is related to trophoectoderm quality, abortion rate live birth rate, but not What known already Measurement has been widely used for early pregnancy detection after assisted reproduction treatments. Shortly implantation, trophoblastic detectable However, several women showed high variability, implantation also depends on endometrial receptivity, what means that stages, everything affecting may affect concentration. Early with higher are scarce information concerning value ongoing rates design, size, duration Retrospective biomedical research 508 patients having single transfer fresh embryos at IVIRMA VIGO clinic 2017 2021 analyse relation concentration, rate. Patients recurrent miscarriage, advanced age, uterine pathologies severe male factor were excluded study. was measured peripherical blood 13 days Participants/materials, setting, methods All generated by ICSI cultured time-lapse incubator under 37ºC, 6% CO2 5% O2 atmosphere. T-Student Youden test kinetics values, Pearson correlation compare gestational successes kinetic data, linear regression model like response variable morphokinetic data explanation variables employed Main results role chance greater A compared B C (ASEBIR classification), 619.53 UI/ml, IC95% (483.16-755.90), 442.24 (350.18-534.31), 269.95 IC95%(88.88-451.01) (p = 0.038) respectively trend Inner cell mass being quality vs 0.053) who had lower those birth, 385.37 (268.45-502.28) 987.53 IU/ml, (845.03-1130.03). T-student analysis index, cut-off points 10 IU/ml 100 employed, analyze morphokinetics, it significant any parameters analyzed Limitations, reasons caution There limited sample size obtained from retrospective donor oocytes this study, although no differences found when they Wider implications findings This study shows top produces more βhCG, could be predictive Trial registration number 1712-VGO-122-EM